The ‘Glutamate Theory’ of the Pathogenesis of Schizophrenia Essay

IntroductionThere is spacious study on the role of glutamate in Schizophrenia. Even so to mesh the current antipsychotics do not control major glutamatergic action albeit a study at the NMDA receptor location such as the genus Glycine transport inhibitors may give new novel evidence for the stripping of future antipsychotics (Olney et al., 1999)The Dopamine hypothesis of Schizophrenia The dopamine (DA) theory of schizophrenic psychosis has subjugated the effort to justify the behaviours Schizophrenia is a psychiatric topsy-turvydom relating to the messing up of routine thinking, sentiment and every day activities. Egan & Weinberger (1979) described dementia praecox as when a subject or an individual is unable to key out what is genuine and unreal. The clinical characteristics of the various disarray of schizophrenic psychosis commonly do it into view in the late adolescence or the early adulthood. Schizophrenia corporation exhibit either positive or negative or two signs . Whereas the positive sign is characterised by paranoia, false principles or hallucination, the negative opinion is marked by depression, withdrawal from communal connections. But pleasing of genial responses shortfall in attention and memory are ascribed to cognitive effect. Generally, schizophrenia is considered to be neurodevelopment unrest rather than neurogenerative disorder (Harrison et al., 2003). There are several(prenominal) divisions in the brain that can be affected by schizophrenia. The unnatural function of the basal ganglia is considered to play a role in paranoia and hallucination. The frontlet lobe of the brain plays a role in problem solving and reasoning. conversely a schizophrenic will have a deficiency in the lobe and as result, having difficulty in forecast and coordinating. Adjustment... ...ts. Neuroscience, 90(3), 823-32.Kim,J.S.,Kornhuber,H.H.,Schmid-Burgk,W.,Hlozmuller,B.(1980) Low cerebrospinal wandering glutamate in schizophrenic patients and a n ew hypothesis on schizophrenia. Neuorocience garner 20379-382 Kotter, H. (1994) Postsynaptic integration of gluamatergic and dopamine signals in the striatum. Progression in Neurobiology. 44163-196 Olney, J. W., Newcomer, J. W., & Farber, B. B. (1999). NMDA receptor hypofunction model of schizophrenia. Journal of Psychiatric Research. 33 523-533.Stanley, J. A., Williamson, P. C., Drost, D. J., Carr, T. J., Rylett, R. J., Malla, A., Thompson R. T. (1996). An in vivo proton magnetic resonance spectroscopy study of schizophrenia patiens. Schizophrenia Bulletin, 22(4), 597-609.Weinberger, D.A (1993) Connection nestle to the prefrontal cortex. Journal of Neuropsychiatry. 5241-253